Renal DOAC Guidance: Dosing adjustment thresholds based on Cockcroft-Gault. Accuracy is critical as renal clearance varies from 25% (Apixaban) to 80% (Dabigatran).
CrCl (mL/min) — Cockcroft-Gault
Verified
Last Review: 2026-07-17
| Agent | CrCl > 50 | CrCl 15 - 50 | CrCl < 15 |
|---|---|---|---|
| Dabigatran | 150 mg bid | Reduce/Stop (30-50) | Contraindicated |
| Rivaroxaban | 20 mg qd | 15 mg qd | Contraindicated |
| Apixaban | 5 mg bid | 5 mg bid (unless AF rule) | Not well studied |
| Edoxaban | 60 mg qd | 30 mg qd | Contraindicated |
Steffel J et al. • Europace. 2021;23(10):1612-1676.
View SourceLast Comprehensive Review: 2026-07-17
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