MRD Sensitivity: Assessing the "depth" of clinical remission. NGS (10⁻⁶) is significantly more sensitive than standard flow.
Sensitivity Threshold
Clinical Use Case
Current NCCN/EHA minimum for MRD-negativity in trials.
Comparison
100x more sensitive than standard flow.
Verified
Last Review: 2026-07-17
| Threshold | Meaning (1 in X cells) | Standard Method |
|---|---|---|
| 10⁻⁴ | 1 in 10,000 | Standard multi-parameter flow |
| 10⁻⁵ | 1 in 100,000 | NGF (Next Gen Flow) / NCCN Minimum |
| 10⁻⁶ | 1 in 1,000,000 | NGS (Next Gen Sequencing) / IMWG standard |
Kumar S et al. • Lancet Oncology. 2016;17(8):e328-e346.
View SourcePaiva B et al. • Leukemia. 2016;30(10):2103-6.
View SourceLast Comprehensive Review: 2026-07-17
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