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MIPSS70+ v2.0 (MF)

MIPSS70+ v2.0: Mutation and Karyotype-enhanced IPSS for Primary Myelofibrosis. Essential for transplant timing in candidates ≤ 70 years.

Clinical Features

Genetic & Molecular

Cytogenetic Risk Class

MIPSS70+ v2.0 Score

0

Risk Category

Low Risk

Estimated Median Survival: > 20 yr

Standard surveillance or targeted therapy (e.g. Ruxolitinib) transition based on symptoms.

Guidelines & Evidence

Verified

Last Review: 2026

When to Use

When to Use

Initial risk stratification in patients with Primary Myelofibrosis (PMF) who are candidates for stem cell transplant.

Integrating clinical features with high-risk mutation status (e.g., ASXL1, SRSF2).

Predicting overall survival and leukemia-free survival in the molecular era.

Patient Population

Adult patients with Primary Myelofibrosis (PMF) aged ≤ 70 years. While designed for younger transplant-eligible cohorts, it is the most robust current model.

When Not to Rely on This Score Alone

Secondary MF (e.g., Post-PV/ET MF) — requires different models like MYSEC-PM.

Patients > 70 years — although applicable, transplant decisions differ in older cohorts.

Incomplete molecular data — MIPSS70+ v2.0 requires high-risk mutation profiling (ASXL1, EZH2, SRSF2, U2AF1 Q157) and cytogenetics.

Last Comprehensive Review: 2026

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